I'm a big proponent of non-grind professions, and of maximizing isk per effort.
To illustrate this concept, consider PI. Supposedly, a plasma planet makes 500m/month. That's not a huge amount of isk, especially over a month of time, but if it only takes you one hour per month to keep it running you are making 500 million isk for one hour of effort.
Traditional grind type professions - mining, exploration, etc. - make numbers like 15-150m/h. In these cases, isk per effort is easy to measure: Work for an hour, and see how much isk you've made. You may have to factor in LP, if you do missions or incursions, or take an average over many hours with exploration, but the principle is the same.
I decided to do this with capital manufacturing. It's a little harder to measure time spent, and there are some grey areas which require consideration. I decided to tally it thusly:
Only time when I have to be at the keyboard counts toward the total. This includes time spent playing with spreadsheets, setting up and modifying buy orders for minerals, jumping minerals to lowsec, installing and delivering jobs, and setting up and modifying sell orders. It does not count time spent autopiloting, but does count the few seconds it takes to drag minerals to/from my cargo on each end of the autopilot route.
Using these criteria I measured the time required to build and sell a 4 ship run consisting of two tier 1 capital ships (carriers) and two tier 2 capital ships (dreadnaughts, rorquals). This came out to almost exactly 1.5 hours. Then I found all the 2x1+2x2 runs since mineral prices stabilized a few months back, which turned out to be only two. That's a very small sample, so I also filled out two 2x1+2x2 runs which are in progress with current lowest sell order prices for their ships.
Averaging the 4 runs returns an average of 1648 million isk in after-tax profit, or 1100 million isk per hour of effort. This is a fairly ballpark figure, but feels approximately correct.
So, newai. That's how I roll.